Information

Selected Bibliography

SSCI Inc. is the publisher of Solid-State Chemistry of Drugs, Second Edition,and Mechanics and Physical Principles for Powders and Compacts, Second Edition. Solid-State Chemistry of Drugs is a comprehensive review of molecular structure in solid drugs, methods of analysis, solid-state physical transformations, and solid-state reactions.
Mechanics and Physical Principles for Powders and Compacts is a concise overview of technologies and fundamental concepts in processing of solids, prediction of tableting and other material properties, and formulation of solid dosage forms.

SSCI Inc. also publishes Application Notes on topics of importance in solid-state pharmaceutical science.

SSCI scientists make presentations at technical and professional conferences and publish in the journals of their respective disciplines. The following is a list of recent publications and presentations by SSCI scientists.

  1. Chyall, L. J.; Tower, J. M.; Coates, D. A.; Houston, T. L.; Childs, S. L. "Polymorph Generation in Capillary Spaces: The Preparation and Structural Analysis of a Metastable Polymorph of Nabumetone" Crystal Growth & Design 2002, 2 , 505-510.
  2. S. L. Childs and K. S. Hagen, Presented at the Royal Society of Chemistry's Crystal Engineering Communications Discussion Conference (2002), CrystEngComm, 2002, 4, 265-270; "A Co-crystal Containing Kemp's Tri-acid and Acetic Acid: A 0D Aggregate Disrupts A Thermodynamically Preferred 1D Rod Motif."
  3. He, X.; Stowell, J.G.; Morris, K.R.; Pfeiffer, R.R.; Li, H.; Stahly, G.P.; Byrn, S.R. "Stabilization of a Metastable Polymorph of 4-Methyl-1,2-nitroacetanilide by Isomorphic Additives" Crystal Growth & Design 2001, 1, 305.
  4. D.E. Bugay, "Characterization of the Solid-State: 2. Spectroscopic Techniques", Adv. Drug Delivery Rev., 48(1), 43-65 (2001).
  5. S. R. Byrn, W. Xu, A. W. Newman, "Chemical Reactivity in Solid-State Pharmaceutics", Adv. Drug Delivery Rev., 2001, 48(1),115-136.
  6. Davidovich, M.; Mueller, R.; Raghaven, K.; Ranadive, S.; Vitez, I.; Sarsfield, B.; DiMarco, J.; Gougoutas, J.; Newman, A. Amer. Pharm. Rev. 2001, 4(1), 53-60; "The Role of Powder X-Ray Diffraction as a Powerful Tool in Characterization of Various Hydrates of a Drug Substance."
  7. Newman, A.W.; Stahly, G.P. in Handbook of Pharmaceutical Analysis; Ohannesian, L.; Streeter, A.J., Eds.; Marcel Dekker: New York, 2001, Chapter 1. Form Selection of Pharmaceutical Compounds.
  8. Bugay, D. E.; Smith, P. A. Presented at the Nicolet Research Symposium 2000-2001; "IR and Raman of Pharmaceuticals, Quantitative Assays and Mapping."
  9. Gandhi, R.B.; Bogardus, J.B.; Bugay, D.E.; Perrone, R.K.; Kaplan M.A. Int. J. Pharm. 2000, 201, 221-237; "Pharmaceutical Relationships of Three Solid State Forms of Stavudine."
  10. Gurney, R.W.; Mitchell, C.A.; Ham, S.; Bastin, L.D.; Kahr, B. J. Phys. Chem. B. 2000, 104, 878-892 ; "Salting Benzenes."
  11. Sharma, R. K.; Hajaligol, M. R.; Smith, P. A.; Wooten, J. B.; Baliga, V. Energy & Fuels 2000, 14, 1083-1093; "Characterization of Char from Pyrolysis of Chlorogenic Acid."
  12. Smith, P.A.; Bugay, D.E.; Houghtaling, M. A . Presented at the 27th Annual Conference of the Federation of Analytical Chemistry and Spectroscopy Societies, 2000; Paper No. 598 (invited); "Chemometric Applications of Mixture Analysis Using FT-Raman Spectroscopy."
  13. Smith, P. A Vibrational Spectroscopy 2000, 24, 47-62; "Infrared microspectroscopy mapping studies of packaging materials: experiment design and data profiling considerations."
  14. Yu, L.; Stephenson, G. A.; Mitchell, C.A.; Bunnell, C.A.; Snorek, S.V.; Bowyer, J.; Borchardt, T.B.; Stowell, J.G.; Byrn, S.R. J. Am. Chem. Soc. 2000, 122, 585-591; "Thermochemistry and Conformational Polymorphism of a Hexamorphic Crystal System."
  15. Yu, L.; Reutzel-Edens, S. M.; Mitchell, C. A., Org. Proc. Res. Dev. 2000, 4, 396-402; "Crystallization and Polymorphism of Conformationally Flexible Molecules: Problems, Patterns, and Strategies."
  16. Bugay, D.E.; Findlay, W.P. Pharmaceutical Excipients: Characterization by IR, Raman, and NMR Spectroscopy; Marcel Dekker: New York, 1999.
  17. McGlynn, P.; Redmon, M. P.; Wald, S. A.; Morrison, H. G.; Newman, A. W.; Russell, B. W.; Stahly, G. P.; Bugay, D. E.; Li-Bovet, L.; Venero, A. F. Presented at AAPS Annual Meeting, November 1999; "Quantitation of Amorphous Material in Micronized Levalbuterol Sulfate."
  18. Newman, A. W.; Vitez, I. M.; Mueller, R. L.; Kiesnowski, C.; Davidovich, M.; Findlay, W. P. Analytical Profiles of Drug Substances and Excipients 1999, 26, 459-502; "Sorbitol."
  19. Newman, A. W.; Stephens, P.; Morrison, H. G.; Andres, M. C.; Thomas, A. S.; Stahly, G. P. Presented at AAPS Annual Meeting, November 1999; "Quantitation of Two Polymorphic Forms Using X-Ray Powder Diffraction and Rietveld Analysis."
  20. Stahly, G.P.; Byrn, S.R. In Molecular Modeling Applications in Crystallization; Myerson, A.S., Ed.; Cambridge University Press: New York, 1999; Chapter 6. "The Solid-State Structure of Chiral Organic Pharmaceuticals."
  21. Chongprasert, S., Griesser, U. J.; Bottorff, A. T.; Williams, N. A.; Byrn, S. R., Nail, S. L . J. Pharm. Sci. 1998, 87, 1155-1160; "Effects of Freeze-Dry Processing Conditions on the Crystallization of Pentamidine Isethionate."
  22. Findlay, W.P.; Bugay, D.E. J. Pharm. Biomed. Anal. 1998, 16, 921-993; "Utilization of Fourier Transform-Raman Spectroscopy for the Study of Pharmaceutical Crystal Forms."
  23. Mitchell, C.A.; Gurney, R. W.; Jang, S.-H; Kahr, B. J. Am. Chem. Soc. 1998, 120, 9726-9727; "On the Mechanism of Room Temperature Phosphorescence."
  24. Morris, K.R., Nail, S.L., Peck, G.E., Byrn, S.R., Griesser, U.J., Stowell, J.G., Hwang, S-J, Park, K. Pharmaceutical Science and Technology Today 1998, 1, 235-245; "Advances in Pharmaceutical Materials and Processing."
  25. Smith, J.; MacNamara, E.; Raftery, D.; Borchardt, T.; Byrn, S. J. Am. Chem. Soc. 1998, 120, 11710-11713 (English); "Application of Two-Dimensional 13C Solid-State NMR to the Study of Conformational Polymorphism."
  26. Vitez, I. M.; Findlay, W. P.; Gallela, M.; Mueller, R. L.; Newman, A. W.; Sarsfield, B.; Swensen, A. K. Presented at Eastern Analytical Symposium and Exposition, November 1998; "Physical Characterization of a Solid Bulk Drug Substance Using a Multi-Disciplinary Approach."
  27. Huang, K-S; Britton, D.; Etter, M. C.; Byrn, S. R., J. Mater. Chem. 1997, 7, ,713-720; "A novel class of phenol-pyridine co-crystals for second harmonic generation."
  28. Rodriguez, C.; Bugay, D. E. J. Pharm. Sci. 1997, 86, 263-266; "Characterization of Pharmaceutical Solvates by Thermogravimetric/Infrared Analysis (TG/IR)."
  29. Shalaev, Evgenyi Yu.; Byrn, Stephen R.; Zografi, George. Int. J. Chem. Kinet. 1997, 29, 339-348; "Single-phase and heterophase solid-state chemical kinetics of thermally induced methyl transfer in tetraglycine methyl ester."
  30. Stahly, G. P.; Starrett, R. M. Chirality in Industry II; Collins, A. N.; Sheldrake, G. N.; Crosby, J., Eds.; Wiley & Sons: New York, 1997, Chapter 3. "Production Methods for Chiral Non-steroidal Anti-inflammatory Profen Drugs."
  31. Stahly, G.P.; McKenzie, A.T.; Andres, M.C.; Russell, C.A.; Byrn, S.R.; Johnson, P. J. Pharm. Sci. 1997, 86, 970. "Determination of the Optical Purity of Ibuprofen Using X-ray Powder Diffraction."
  32. Stephenson, G. A.; Stowell, J. G.; Toma, P. H.; Pfeiffer, R. R.; Byrn, S.R. J. Pharm. Sci. 1997, 86, 1239-1244; "Solid-State Investigations of Erythromycin A Dihydrate Structure, NMR Spectroscopy, and Hygroscopicity."
  33. Stephenson, G. A.; Pfeiffer, R. R.; Byrn, S. R., Int. J. Pharm. 1997, 146, 93-99; "Solid-state investigation of the tautomerism of acetohexamide."
  34. Xu, W.; Wahle, M. C.; Stowell, J. G.; Byrn, S. R. Acta Crystallogr., Sect. C: Cryst. Struct. Commun. 1997, C53, 1917-1919; "Spirapril hydrochloride hydrate.