Molecular spectroscopy is a widely recognized technique for the characterization of solid-state materials. Numerous advantages exist with molecular spectroscopy, namely qualitative and quantitative analysis, real-time monitoring of transient species, the ability to study API or drug product, and more recently, process analytical technology (PAT) application. Due to these advantages, SSCI utilizes molecular spectroscopy for standard compendial methodology, but also for high-end research applications. Because of the wide range of spectroscopic instrumentation at SSCI, we can apply the appropriate technology to our customers needs.
SSCI performs solid-state analyses with state-of-the-art infrared (IR), near IR (NIR) and Raman spectrometers. Each of these techniques can provide both qualitative characterization of different solid forms and a means to quantitate the solid form composition within the drug substance or product.
Diffuse Reflectance
Alkyl Halide Pellet
Mineral Oil Mull
TG/IR
Microspectroscopy
Variable Temperature Diffuse Reflectance
Variable Humidity Diffuse Reflectance
Attenuated Total Reflectance
Grazing Angle
Chemical Mapping
Dispersive and FT-Raman Spectrometers
Microspectroscopy
Chemical Mapping
Variable Temperature
As an industry standard, ultraviolet/visible absorption spectroscopy is used by SSCI in support of dissolution, stability, and solubility studies.