The water adsorption/desorption profile of a solid provides key information related to the physical stability of solid forms, especially hydrates. We can investigate the moisture uptake of samples at various relative humidities and temperatures using moisture sorption balances and/or gravimetric methods, and can fully characterize any new forms observed. We've used this technique extensively to quantitate amorphous material in drug substance.
Organic vapor sorption can provide information on solvated forms and can be used for quantitation when water sorption may not be appropriate. In addition, physical stability of amorphous materials can be explored using various organic vapors.
Karl Fischer
Loss on Drying
TGA
IR and Near IR
NMR